The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01325844

Enrollment

Registered

2011-03-30

Start date

2010-11-30

Completion date

2011-10-31

Last updated

2012-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate Cancer

Brief summary

This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.

Interventions

PROCEDUREEpidural anesthesia

0.5% ropivacaine infusion via epidural catheter at 5ml/hr during general anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy

Exclusion criteria

* Patient refusal * Patients on diuretics * Patients with renal failure (eGFR \< 60 ml/min/1.73 m2)

Design outcomes

Primary

Measure	Time frame
blood pressure with heart rate variability	10 minutes after anesthesia induction

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026