Major Depression
Conditions
Brief summary
In order to explore the effect of repetitive TMS, which has shown to be effective in intractable depression, we will examine resting-state, default-mode network functional connectivity in patients with major depression. We will use a double-blind, sham-controlled design. Our target sample size is 60(30 patients will be treated by active rTMS, the other 30 will be treated by sham rTMS). We will apply 10-day course of 10 Hz rTMS on left dorsolateral prefrontal cortex of the subjects.
Detailed description
Up to now, 24 patients with major depression and 6 normal controls are enrolled. Twenty-three patients and 4 normal participants have taken 10 days rTMS. One patients and one control withdrew their consent without any reason and one control withdrew the consent because of headache. We scanned fMRIs(to examine functional connectivity)twice for each participant, which were taken 3 days before the first and 3 days after the last rTMS. All of participants have not reported side effects except mild headahe. There's been no seizure event up to now.
Interventions
10-day course of 10 Hz rTMS on left dorsolateral prefrontal cortex of the subjects.
DEVICESham repetitive transcranial magnetic stimulation(rTMS)
Sham repetitive transcranial magnetic stimulation(rTMS)
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
19 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* DSM-IV major depressive episode * Failure of at least 3 different kind of antidepressant
Exclusion criteria
* Organic brain disorder * Other diagnosis of DMS-IV except nicotine dependence * History of seizure disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of functional connectivity between pre/post rTMS | 14 days |
Countries
South Korea
Outcome results
None listed