Atrial Fibrillation
Conditions
Keywords
Atrial fibrillation, Motor activity
Brief summary
The purpose of this study is to determine the effect of aerobic interval training in patients with paroxysmal or persistent atrial fibrillation, especially to see if the burden of atrial fibrillation and symptoms are reduced.
Detailed description
Long term endurance sport practice is associated with a higher incidence of atrial fibrillation. Moderate/light physical activity seems to be associated with a lower incidence. The underlying mechanisms are uncertain. In order to examine the effect of training in this population, the investigators will perform a randomised controlled study with aerobic interval training in patients with paroxysmal/persistent atrial fibrillation.
Interventions
BEHAVIORALInterval training
Aerobic interval training will be performed with 4 times of 4 minutes intervals at an intensity of 90-95% of maximum heart rate and active pauses of 3 minutes between intervals. 3 times a week for 12 weeks.
Sponsors
St. Olavs Hospital
SINTEF Health Research
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients with paroxysmal or persistent atrial fibrillation, that are able to perform aerobic interval training.
Exclusion criteria
* Performing high intensity training (pulse \>90% of max) for more than 2 times a week. * Moderate intensity training more than 30 min, more than 3 times a week * Previous open heart surgery * EF \<40% * Significant aorta stenosis * Mitral insufficiency, \>gr. 2 * Pacemaker * Earlier coronary intervention and not complete revascularization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in burden of atrial fibrillation | Baseline and 4 weeks after ended intervention period | Burden of atrial fibrillation(number of episodes, duration(percent of the day)) continually measured, and reported by the patient. Analysed for the patients in total, with sub analysis in the groups of paroxysmal and persistent AF and in those with a low burden of atrial fibrillation vs. those with a larger burden. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood samples | Baseline and after ended intervention period(12 weeks) | Interleukin-6, pro-BNP, d-dimer and von Willenbrands factor are measured. |
| Endothelial function | Baseline and after ended intervention period(12 weeks) | FMD |
| Atrial extrasystoles | Baseline and after ended intervention period(12 weeks) | Atrial extrasystoles on 48h Holter monitoring. Will alse be measured in the first week of training. |
| Ablation procedure | Measured during the ablation procedure (day 1) | Duration of ablation, number of ablation points, success. |
| Size of left atrium and ventricle | Baseline and after ended intervention period(12 weeks) | Atrial and ventricular size will be evaluated by echocardiography and MRI. |
| Atrial and ventricular function | Baseline and after ended intervention period(12 weeks) | Atrial and ventricular function measured by MR and echocardiography |
| Fibrosis | Baseline and after ended intervention period(12 weeks) | Fibrosis in left atrium and left ventricle measured by MRI. |
| Quality of life | Baseline and after ended intervention period(12 weeks) | Measured with SF-36, Symptom and Severity Checklist and EHRA score of AF- related symptoms |
| Burden of atrial fibrillation in the intervention period | Week 1-4, 5-8 and 9-12 | The intervention period is divided into 3 periods of 4 weeks each. The mean burden of atrial fibrillation(percent of time with atrial fibrillation) and number of episodes in each of those periods will be assessed to see if exercise changes the amount of fibrillation. |
| Maximal oxygen uptake | Baseline and after ended intervention period(12 weeks) | — |
Countries
Norway
Outcome results
None listed