Atrial Fibrillation, Stroke
Conditions
Keywords
Stroke, Atrial Fibrillation
Brief summary
About one-third of patients with stroke have no documented cause for the cerebrovascular event (known as cryptogenic strokes). Atrial fibrillation is a common cause of stroke, but when transient (paroxysmal) it may remain undiagnosed. Recent data suggest that occult paroxysmal atrial fibrillation may be identified in patients with cryptogenic strokes using prolonged ambulatory cardiac rhythm monitors. The investigators designed this study pursuing the following goals: 1. To determine the prevalence of occult paroxysmal atrial fibrillation in patients with cryptogenic stroke using long-term mobile cardiac outpatient telemetry. 2. To compare this prevalence to that found in a control group with stroke of known, non-cardioembolic cause. 3. To look for clinical, laboratory, echocardiographic, and imaging data that serve as risk factors for occult paroxysmal atrial fibrillation in patients with cryptogenic stroke. 4. To examine the utility of mobile cardiac outpatient telemetry, a relatively new diagnostic tool, in the evaluation of patients with cryptogenic stroke.
Interventions
OTHERMobile cardiac rhythm monitoring
Continuous ambulatory cardiac rhythm monitoring using the CardioNet MCOT device
Sponsors
Cardionet
Mayo Clinic
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Stroke or TIA within previous 3 months * Stroke work up including: EKG, serum lipids, serum TSH, TTE or TEE, brain CT and/or MRI, Vascular Evaluation of head and neck using any combination of ultrasound, MRA, CTA, and conventional angiography
Exclusion criteria
* Documented history of atrial fibrillation or flutter * PFO closure planned before conclusion of the monitoring period * Incomplete stroke work up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of Atrial Fibrillation | 21 days | Documented presence of atrial fibrillation detected by the monitoring device and independently confirmed by a board-certified cardiologist |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to first episode of atrial fibrillation | Within monitoring period (3 weeks) | — |
| Atrial Fibrillation Load | Within monitoring period (3 weeks) | Total time that the patient had atrial fibrillation during the monitoring period |
| Adverse events related to mobile cardiac monitoring | 21 days | — |
| Symptomatic status of episode of atrial fibrillation | 21 days | Presence or absence of symptoms related to the occurrence of paroxysmal atrial fibrillation |
| Longest duration of episode of atrial fibrillation | 21 days | — |
Outcome results
None listed