Diabetes Mellitus
Conditions
Keywords
Carotid Artery Diseases, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Peripheral Vascular Diseases, Retinal Vessels
Brief summary
Background: The purpose of this study is to analyze the relationship between central and peripheral blood pressure (clinic and ambulatory) with vascular structure and function, assessed by carotid intima-media thickness (IMT), artery venous retinal index, pulse wave velocity (PWV) and ankle-brachial index in patients with diabetes type 2 and without diabetes type 2. Develop and validate a software to measure the retinal vessels and to estimate arterio-venous index automatically. Methods/design: The investigators will Perform a coss-sectional study with control group, with follow-up of 4 years in primary care. The study population will be diabetic type 2 patients with a control group without diabetes mellitus. The investigators will include by consecutive sampling 300 patients between 34 and 75 and without previous cardiovascular disease, half of each group. Main measurements: age, sex, height, weight and waist circumference. Lipids, creatinine, microalbuminuria, blood glucose, HbA1C, insulin, fibrinogen, hs-CRP and markers of endothelial dysfunction. Clinic and ambulatory blood pressure (MAPA). Ultrasonography to assess carotid IMT, retinography to assess arterio-venous ratio. ECG to evaluate left ventricular hypertrophy, ankle-brachial index and morphology analysis (PWA) and pulse wave velocity (PWV) in Sphigmocor System. Discussion: The investigators provide information regarding various parameters derived from MAPA and pulse wave analysis of with target organ damage, especially with the vascular structure and function assessed by IMT and PWV and endothelial dysfunction in patients with diabetes type 2 and without this disease. The investigators also hope to demonstrate the usefulness of the tool developed for automatic evaluation of retinal vascularization in the early detection of abnormalities of vascular structure and function and the prognosis of cardiovascular disease in the medium term.
Interventions
None listed
Sponsors
Castilla-León Health Service
Carlos III Health Institute
Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
34 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 34 years or more but less than 75 years, with and without type 2 diabetes.
Exclusion criteria
* Patients who fail to meet the requirements of the protocol (mental disorders and / or cognitive uncooperative, education and understanding limitations), * Patients with ischemic heart disease, cerebrovascular disease or other atherosclerotic disease * Patients who are participating or will participate in a clinical trial during the study * Patients with serious comorbidity that might endanger his life in the next 12 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| subclinical organ damage | december, 1 2013 |
Countries
Spain
Outcome results
None listed