Abdominal Obesity, Physical Activity
Conditions
Keywords
Childhood obesity, Visceral fat, Insulin resistance, Liver fat, Skeletal muscle lipid, Regular exercise
Brief summary
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, ectopic fat in the liver and skeletal muscle, and risk of type 2 diabetes in overweight girls.
Interventions
OTHERControl
Standard care control (no exercise)
OTHERResistance Exercise
Supervised resistance exercise using stack weight equipments.
OTHERAerobic exercise
Supervised aerobic exercise using treadmills, bikes, and ellipticals
Sponsors
University of Pittsburgh
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
12 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy overweight (BMI \>-95th) youth between 12 and 18 years of age * Waist circumference \>-75th percentile * Sedentary (no structured exercise \>2 times/week for past 6 months) * Non-smokers, non-diabetic, no medical conditions * Weight stable for past 3 months
Exclusion criteria
* Smokers * Diabetes * Psychiatric disorders * Syndromic obesity * Pregnancy * Taking medications known to affect study outcomes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abdominal obesity, visceral fat | 3 month |
Secondary
| Measure | Time frame |
|---|---|
| insulin sensitivity by a 3-hour hyperinsulinemic-euglycemic clamp, oral glucose tolerance test, liver fat and intramyocellular lipid by 1H-magnetic resonance spectroscopy. | 3 month |
Countries
United States
Outcome results
None listed