Diabetes, Renal Insufficiency
Conditions
Brief summary
The primary objective is to demonstrate a longer period of neurologic recovery from a sensory block assessed in each test group versus the group without metabolic disease.
Interventions
PROCEDURETruncal block
Patients will have a truncal block during hand or wrist surgery.
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
General Inclusion Criteria: * The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan * The patient is available for 1 month of follow up * The patient is scheduled for hand or wrist surgery Inclusion Criteria for the Renal Insufficiency group * Patient has renal insufficiency as defined by a creatine clearance of \< 30ml/min without dialysis Inclusion Criteria for the Diabetes group * Patient has chronic hyperglycemia, either a fasting glycemia \> 1.26 g/l (7mmol/l) for longer than 5 years and receiving an oral, well-adjusted (last HBA1c \< 6.5%)), non-insulin, antidiabetic treatment Inclusion Criteria for the Non-exposed group * Patient without metabolic or neurologic disease, with creating clearance \> 90ml/min
Exclusion criteria
* The patient is participating in another study * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection, under tutorship or curatorship * The patient refuses to sign the consent * It is impossible to correctly inform the patient * The patient is pregnant * The patient is breastfeeding * Patient weighs less than 50 kg * Score ASA \> 4 * contra indication for locoregional anesthesia * Severe metabolic and / or decompensated renal disease, cardiac or pulmonary decompensation * Associated peripheral neuropathy associated with diabetes or kidney disease * Associated central neuropathy associated (eg MS ... narrow cervical canal) * Patients with both renal failure and diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The duration of sensory block in minutes. | Day 0 (per-op) | The duration of the sensory block in minutes. The beginning of this term is defined by the end of the axillary block (last injection), and the end of this period is defined by the reappearance of sensitivity to touch in the area anesthetized. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of neurological complications, yes/no | Day 0 (post-op) | Neurological: occurrence of complications (paresthesia, paralysis, paresis ....) that persist (or not) until the final postoperative evaluation |
| Time necessary for completion of axillary blocks (1 / 3 upper humerus)(min) | Day 0 (per-op) | — |
| Time necessary for installing sensory and motor block (min) | Day 0 (per-op) | Time necessary for installing sensory and motor block (min): defined by the delay between the end of the block injection and the occurrence of insensitivity of blocked territories |
| Failure of the block: yes / no | Day 0 (per-op) | Failure of the block: yes / no: defined by an absence of sensory block |
| Presence of paresthesia: yes / no | Day 0 (per-op) | — |
Countries
France
Outcome results
None listed