Diabetic Foot, Osteoarthritis
Conditions
Brief summary
The investigators' primary objective is to assess the predictive power of PET/CT scanning in the evolution of infectious osteoarthritis of the diabetic diabetic after antibiotic therapy prescribed by national and international recommendations.
Interventions
PROCEDUREBone scintigraphy
Bone scintigraphy of the affected area
PROCEDURELeukoscan
Scintigraphy with labeled neutrophils
PROCEDUREPET / CT
PET / CT of the affected area
PROCEDUREBone biopsy
A bone biopsy is performed during pre-inclusion work up.
BIOLOGICALBloodwork
CRP and procalcitonin are measured in the pre-inclusion work up.
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan * Patient has type I or type II diabetes * Patient consulting in the department of Metabolic and Endocrine Diseases (Caremeau Hospital) or the department of Nutritional Diseases and Diabetology (Grau de Roi Medical Center) at the Nîmes University Hospital * Patient has infected osteoarthritis of the foot according to the International Working Group on the Diabetic Foot with a probability \> 50% (score \>= 2).
Exclusion criteria
* The patient is participating in another study * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection, under tutorship or curatorship * The patient refuses to sign the consent * It is impossible to correctly inform the patient * The patient is pregnant * The patient is breastfeeding * Patient has severe sepsis or a stage 4 infection according to the international consensus on the diabetic foot * Patient has severe renal insufficiency as defined by glomerular filtration rate \< 30ml/min/1.73 m\^2, calculated according to the MDRD equation, and is not undergoing dialysis * Patient has a contra-indication for an MRI * pacemaker * intracranial clips * metallic inclusions * severe claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference between AUCs for PET/CT scan and scintigraphy | 1 year |
Countries
France
Outcome results
None listed