Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)

The Relation Between Systemic Inflammatory Markers and Acute Pain in TKA

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01322074

Enrollment

120

Registered

2011-03-24

Start date

2009-08-31

Completion date

2011-10-31

Last updated

2011-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other Acute Postoperative Pain, Systemic Inflammatory Response Syndrome

Keywords

Acute postoperative pain, systemic inflammation, CRP, IL6

Brief summary

In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

Detailed description

The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated. Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation). We pole blood-samples collected prospectively (from two data set)

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Elective unilateral primary total knee arthroplasty * Able to speak and understand danish * Able to give informed consent

Exclusion criteria

* Alcohol or medical abuse * Allergies to local anesthetics or methylprednisolone * Age \< 18 years old * Daily use of strong opioids or glucocorticoids * Pregnancy or breastfeeding (fertile women) * Bilateral / revision arthroplasty * Dementia or other cognitive dysfunction * Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception

Design outcomes

Primary

Measure	Time frame	Description
Systemic inflammation vs. pain	1 week	The correlation between pain and systemic inflammatory markers (CRP and IL6)

Countries

Denmark

Outcome results