Dietary Fiber
Conditions
Keywords
dietary fiber, enteral nutrition, laxation
Brief summary
Dietary fiber is known to influence bowel function. The investigators hypothesize that the addition of a mixture of fibers to liquid diets will improve bowel function as measured by stool weight.
Detailed description
Liquid diets are the sole source of nutrition for many patients. Consumption of liquid diets is linked to lower stool weight. The objective of this study is to feed liquid diets, with and without added fiber, to healthy human subjects to determine if mixed fiber sources can normalize stool weight. Secondary objectives of the study include measurement of gut microbiota and stool chemistry with fiber addition.
Interventions
DIETARY_SUPPLEMENTdietary fiber
mixture of fiber sources added to liquid nutrition product
Sponsors
Société des Produits Nestlé (SPN)
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1.Weight * BMI between 23 - 29 * having obtained his/her informed consent * willing and able to exclusively consume enteral diets for two 14 day periods * willing and able to collect stool samples as instructed
Exclusion criteria
* any disease * use of medication except for contraceptive medication and certain OTC medications not affecting laxation * smoking * excessive exercise (\> 2 hours per week) * consumption of more than 20 grams of dietary fiber daily * pregnancy or lactation * use of laxatives * use of antibiotics in past 6 months * use of pre or probiotics supplements in the past 2 months * use of probiotic foods in the past month * subjects who cannot be expected to comply with the study procedures * currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study * known allergy or sensitivity to formula ingredients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stool weight | 5 day collection | 5 day fecal collection on last 5 days of 14 day feeding trial |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fecal microbiota | day 14 of feeding trial | fecal sample on last day of feeding trial will be collected for microbiota analysis |
Countries
United States
Outcome results
None listed