Colorectal Neoplasms
Conditions
Keywords
Geriatric Assessment, Perioperative Care, Colorectal Neoplasms, Frail Elderly
Brief summary
This is a randomized, controlled trial on frail elderly patients (aged 65+) with colorectal cancer. The patients will be randomized into two groups. The control group will receive standard surgical treatment. The intervention group will in addition go through a preoperative comprehensive geriatric assessment. The assessment will include evaluation of co-morbidity and medication, social status, nutritional status, cognition, depression and physical performance. This assessment will form basis of an individualized perioperative intervention. The main aim of the study is to see if the number of postoperative complications in this group can be reduced by a perioperative geriatric intervention. A study of inflammation markers in serum will also be performed, with focus on identifying potential biological frailty markers.
Interventions
A comprehensive geriatric assessment (CGA), focusing on co-morbidity, medication, cognitive status, depression, nutritional status and physical status is performed. The intervention is individualized according to the results of the CGA.
Sponsors
Norwegian Cancer Society
University Hospital, Akershus
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 65+ * Elective surgery for colorectal cancer * Frail
Exclusion criteria
* Acute surgery * Not able to consent * Does not consent with registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative complications | 30 days after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Readmission | 30 days after surgery | Number of patients being readmitted to hospital within 30 days after operation for colorectal surgery. |
| Length of hospital stay | 30 days after surgery | — |
| Reoperation | 30 days after surgery | Number of patients in need of any operation within thirty days after the operation for colorectal cancer. |
| Quality of life | 3 months after surgery | — |
| Living at home or in institution | 3 months after surgery | Number of patients living at home, with or without formal help, and number of patients living in nursing homes 3 months after surgery. |
| Survival | 3 months after surgery | — |
Countries
Norway
Outcome results
None listed