Heart Disease
Conditions
Brief summary
This study will use excess tissue from endoscopic or surgical procedures to examine the elements of plaque that are found in the carotid walls of patients who have a type of heart and blood vessel disease called atherosclerosis. Tissue will be collected from patients undergoing carotid procedures as well as patients undergoing liver and/or intestinal biopsies. This lab study will examine the different types of proteins that play a role in developing heart plaque.
Interventions
None listed
Sponsors
Merck Sharp & Dohme LLC
Piedmont Healthcare
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥18 years * Scheduled for a clinically indicated, standard-of-care carotid endarterectomy (CEA) OR scheduled for a clinically indicated, standard-of- care surgical, laparoscopic or endoscopic intestinal biopsy or excision OR scheduled for a clinically indicated, standard-of-care surgical, laparoscopic or endoscopic liver biopsy or partial resection/excision * Ability and willingness to consent and Authorization for use of PHI
Exclusion criteria
* Age ≤18 years * Inability or unwillingness to consent and Authorization for use of PHI * FOR CAROTID PATIENTS - history of carotid trauma, that is determined by the Principal Investigator to significantly have changed the carotid tissue structure * FOR CAROTID PATIENTS - history of middle- or large-vessel vasculitis, that is determined by the Principal Investigator to significantly have changed the carotid tissue structure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demonstrated Plaques | up to 30 months | Presence of both liver and intestinally derived lipoprotein particles demonstrated in human atherosclerotic plaques. |
Outcome results
None listed