Vitamin C Supplementation Plus Hypoglycemic Agents Versus Hypoglycemic Agents Alone in Type 2 Diabetes Mellitus

Phase 1 Study of Randomized Clinical Trial Comparing Vitamin C Supplementation Plus Oral Hypoglycemic Drugs Versus Hypoglycemic Drugs Alone on Serum Selenium, Zinc, Copper and Malondialdehyde Levels in Type 2 Diabetes Mellitus and Its Microvascular Complications

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01319734

Acronym

Vit C

Enrollment

Registered

2011-03-22

Start date

2011-02-28

Completion date

Unknown

Last updated

2013-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Keywords

Vitamin C, Oxidative stress, Type 2DM

Brief summary

Null hypothesis: No significant effect of vitamin C 500 mg Supplementation on the severity of micro-vascular complications of type 2 Diabetes Mellitus (DM). Alternative hypothesis: There is a significant effect of vitamin C 500mg supplementation on the severity of the micro-vascular complications of type 2DM.

Interventions

DIETARY_SUPPLEMENTVitamin C

Vitamin C supplementation 500mg

DRUGglyburide

this group receiving glyburide 5 mg alone

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* clinical diagnosis of type 2DM * patients in good health * receiving oral hypoglycemic drugs

Exclusion criteria

* Insulin dependent diabetes * receiving vitamin complex * smoking * renal disease * liver disease

Design outcomes

Primary

Measure	Time frame	Description
improving the renal function	the renal function will be measure at day 1 and after one month	vitamin c supplementation act as an antioxidants which reduce the oxidative stress and then can improve the renal function.

Secondary

Measure	Time frame	Description
Vitamin C can improve the visual fields	the visual field will be assesed at day 1 and after one month	the damage of the eye can be prevented by decreasing the oxidative stress in the eye, this can be accomplished by vitamin C.

Countries

Sudan

Contacts

Primary ContactHamdan Z Hamdan, MBBS, Msc

hamdanology@hotmail.com+249912468264

Backup ContactMaha I Mohammed, MBBS, PhD

+249912230895

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026