Cardiac Arrhythmias, Sudden Cardiac Death
Conditions
Keywords
change of potassium amount, circadian and day-to-day variability
Brief summary
The potassium value is important to prevent cardiac arrhythmias and sudden cardiac death. In patients with renal failure, the potassium value is not stable and tends to raise. Until now there are no data available if the potassium value has a circadian rhythm and if there are individual changes from day to day.
Detailed description
Potassium and cystatin c is measured every 2 hours during 24 hours, twice. There are two groups of patients: Patients with eGFR \< 60 ml/min and patients with eGFR \> 60 ml/min
Interventions
PROCEDUREBlood withdrawal
blood withdrawal every 2 hours during 24 hours
Sponsors
Biotronik SE & Co. KG
University of Erlangen-Nürnberg Medical School
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* at least 18 years old * normal renal function and impaired renal function (GFR \< 60 ml/min) respectively
Exclusion criteria
* pregnancy * anaemia (Hb\<10 mg/dl)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Potassium rhythm | twice in 24 hours | 15 persons with normal renal function are hospitalized for 24 hours. Blood samples are taken every 2 hours in order to investigate the potassium value. It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Potassium value in renal failure | twice in 24 hours | 15 persons with renal failure (GFR \< 60 ml/min) are hospitalized for 24 hours. Blood samples are taken every 2 hours in order to investigate the potassium value It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days. |
Countries
Germany
Outcome results
None listed