Depression
Conditions
Keywords
depression, bispectral index, electroconvulsive therapy, magnetic seizure therapy
Brief summary
Electroconvulsive therapy (ECT) has been shown to be an effective treatment for patients suffering from depression, who do not respond to medical treatment. However it is often dismissed by patients, who feel uncomfortably about the application of electric shocks to their heads. In 2000, magnetic seizure therapy (MST) has been introduced which uses magnetism instead of electricity to evoke convulsions. MST seems to be as effective as ECT in terms of its antidepressant potency but may be associated with less severe cognitive side effects. Control of anaesthesia during seizure therapy is demanding since light anesthesia might be associated with awareness, whereas deep anesthesia impedes the antidepressant effect of the convulsion. Therefore, Bispectral index (BIS) monitoring is frequently used to tailor anaesthesia for ECT, however little is known about BIS following MST. The investigators hypothesize that in comparing MST with ECT, (a) patients show a faster increase in BIS and that (b)less left-right differences occur in BIS.
Interventions
None listed
Sponsors
University Hospital, Bonn
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* depression
Exclusion criteria
* age \< 18 years old * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recovery Time | same day | recovery time from seizure induction to eye opening / restoration of breathing |
Countries
Germany
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Magnetic Seizure Therapy Group Patients receiving magnetic seizure therapy for depression | 10 |
| Electroconvulsive Therapy Group Patients receiving electroconvulsive therapy for depression | 10 |
| Total | 20 |
Baseline characteristics
| Characteristic | Magnetic Seizure Therapy Group | Electroconvulsive Therapy Group | Total |
|---|---|---|---|
| Age, Continuous | 45 years STANDARD_DEVIATION 14 | 55 years STANDARD_DEVIATION 12 | 50 years STANDARD_DEVIATION 14 |
| Region of Enrollment Germany | 10 participants | 10 participants | 20 participants |
| Sex: Female, Male Female | 3 Participants | 4 Participants | 7 Participants |
| Sex: Female, Male Male | 7 Participants | 6 Participants | 13 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 10 | 0 / 10 |
| serious Total, serious adverse events | 0 / 10 | 0 / 10 |
Outcome results
Primary
Recovery Time
recovery time from seizure induction to eye opening / restoration of breathing
Time frame: same day
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Magnetic Seizure Therapy Group | Recovery Time | 3.0 minutes | Standard Deviation 1 |
| Electroconvulsive Therapy Group | Recovery Time | 6.7 minutes | Standard Deviation 1.3 |