Muscle Synthesis
Conditions
Brief summary
Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase mitochondrial mass, and/or improve muscle tissue repair. The goal of this proposal will be to provide further insight into the responsiveness of the muscle protein synthetic machinery to food intake in relation to age.
Interventions
DIETARY_SUPPLEMENTProtein
Protein drink
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
65 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Males * Age between 65 and 80 years * BMI \< 30 kg/m2
Exclusion criteria
* Type 2 diabetic patients * Use of medication * All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. artrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Use of anticoagulants, blood diseases, allergy for lidocain. * Contra indications for the use of a nasogastric tube: high risk of aspiration, gastric stasis, gastro-oesophageal reflux, upper gastrointestinal stricture, nasal injuries and base of skull fractures. * Patients suffering from PKU (Phenylketonuria).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Protein synthesis | overnight (12 h) | Overnight protein synthesis |
Countries
Netherlands
Outcome results
None listed