Factors Related to the Progression of Chronic Kidney Disease

The Impact of FGF23 and Klotho on Progression of Chronic Kidney Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01317173

Enrollment

Registered

2011-03-17

Start date

2008-03-31

Completion date

2011-06-30

Last updated

2011-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease

Keywords

Chronic kidney disease progression, FGF 23, Klotho

Brief summary

Chronic kidney disease is a progressive disorder that has been influenced with many factors. Most of the patients has altered Ca P metabolism and these dis orders are the contributing factors of the disease progression. It has been recently documented that FGF23 and Klotho are the key factors of PTH secretion Ca-P metabolism. This study aimed to evaluate the impact of Klotho and FGF23 on the progression of stage 3-4 chronic kidney disease.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Non-diabetic chronic kidney disease

Exclusion criteria

* Presence of DM * Actively using calcium based phosphorus binder of vitamin D

Design outcomes

Primary

Measure	Time frame	Description
Progression of kidney disease	continuous measurement of kidney functions 3 monthly for two years or until the outcome reached	Doubling of creatinin, requirement of renal replacement therapy

Secondary

Measure	Time frame	Description
Evaluation of Ca P metabolism	3 monthly for two years or until the outcome reached	Determination of Ca-P metabolism disorders.

Countries

Turkey (Türkiye)

Outcome results