Age-Related Macular Degeneration
Conditions
Keywords
human study, AMD, lutein, zeaxanthin, optical density
Brief summary
The objective of the study was to investigate the influence of a intervention with lutein und zeaxanthin from crucifers on the optical density of the macular pigment of patients with non exudative age-related maculopathy. It is hypothesized that the applied study beverage elevates plasma concentrations of the administered xanthophylls and the optical density after 4 weeks of intervention.
Interventions
DIETARY_SUPPLEMENTVerum
10 subjects consume for 4 weeks a beverage containing 10 mg lutein and 3 mg zeaxanthin per day
DIETARY_SUPPLEMENTPlacebo
10 subjects consume for 4 weeks a placebo beverage without any lutein and zeaxanthin
Sponsors
University of Jena
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients with non exudative age-related maculopathy
Exclusion criteria
* intake of dietary supplements containing lutein and zeaxanthin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optical density of macular pigment in AMD patients | 10 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of xanthophylls in plasma of AMD patients | 10 weeks |
| blood lipids | 10 weeks |
Countries
Germany
Outcome results
None listed