Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01315782

Enrollment

Registered

2011-03-15

Start date

2026-12-31

Completion date

2026-12-31

Last updated

2025-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multi-organ Failure, Sepsis, Septic Shock, Severe Sepsis

Keywords

Sepsis, Severe sepsis, Septic shock, Alveolar dead space, Multi-organ failure

Brief summary

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Detailed description

The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation. Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults with severe sepsis or septic shock on mechanical ventilation * Enrolled in the initial six hours of ICU admission

Exclusion criteria

* Patients with withdrawal or hospice order. * Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission. * Patients with COPD. * Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Design outcomes

Primary

Measure	Time frame	Description
Multi-organ failure	daily for 48 hours then weekly for 2 weeks.	Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.

Secondary

Measure	Time frame	Description
Mortality	ICU mortality	All the patient will be followed up to 28-days to determine survival.

Countries

United States

Contacts

Primary ContactRosa M Estrada-Y-Martin, MD MSc

rosa.m.estrada.y.martin@uth.tmc.edu713-500-6830

Outcome results