Alzheimer's Disease and Related Disorders

Maladie d'Alzheimer et Maladies apparentées : Caractérisation Des Anomalies Cognitivo-motrices, et Des Effets Des médicaments Anti-démence et de la Vitamine D à Partir de la Mise en Place d'Une Base de données au CMRR du CHU d'Angers

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01315704

Acronym

MERE

Enrollment

700

Registered

2011-03-15

Start date

2009-11-30

Completion date

2017-11-30

Last updated

2011-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease, Gait Apraxia, Impaired Cognition

Brief summary

The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild and moderate dementia stages); to determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities; and to establish a database at Angers University Memory Centre.

Detailed description

Although gait disorders are frequently associated with Alzheimer's disease and related disorders (ADRD), few studies have focused on cognitive motor effects of anti-dementia drugs and vitamin D. The objectives of this study are to * Compare characteristics of gait and balance measured among patients with ADRD separated into 3 groups according to stages of disease (i.e., pre-dementia, mild and moderate dementia stages) * To determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities * To determine whether motor abnormalities could be associated with cognitive impairments, specifically executive dysfunctions * To establish a database at Angers University Memory Center.

Interventions

DRUGDrug intervention

before-after interventional (anti-dementia drugs and/or vitamin D) study

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* All elderly patients from the University Memory Center of Angers University Hospital. * Able to walk without any walking aid on 15 meters * Mini-Mental Status Examination score \> 10 * Being affiliated to a social security regime

Exclusion criteria

* Mini-Mental Status Examination score ≤ 10 * Subject suffering from pre-existing impellent disturbances * History of cerebrovascular accident or other cerebro-spinal pathology * Poor workmanship of the written or oral French language * Use of walking aid such as walking frame with wheels or tricycle. * Acute medical or surgical disease in the past 3 months * Refusal to participate (or trustworthy person) * Near visual acuity \< 2/10

Design outcomes

Primary

Measure	Time frame
Spatiotemporal gait parameters	baseline

Countries

France

Contacts

Primary ContactCedric ANNWEILER, DM

ceannweiler@chu-angers.fr(+33) 241354725

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 22, 2026