Infertility
Conditions
Keywords
improving pregnancy rate and endometrial thickness
Brief summary
The investigators use granulocyte colony-stimulating factor (GCSF) for the treatment of recurrent implantation failure in IVF patient with cause unknown or due to thin endometrium. Several studies showed that GCSF improves embryo development and implantation and increase pregnancy rate.
Detailed description
The investigators use granulocyte colony-stimulating factor (GCSF) for the treatment of repeated implantation failure (5 cycles) in IVF patient with cause unknown or due to thin endometrium. we intend to treat with GCSF during the IVF cycle if thin endometrium (\<6 mm) is the cause for the treatment failure, and during the implantation window if cause unknown.
Interventions
DRUGneupogen administration for women with recurrent IVF failure
neupogen 300 mcg - twice
Sponsors
Hadassah Medical Organization
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
1. women after 5 failures in IVF cycles with cause unknown. 2. women after 5 failures in IVF due to thin endometrium (\<6 mm) and unresponsive to estrogen supplements.
Exclusion criteria
1. history of hematology disease 2. allergy to GCSF 3. neutrophilia 4. severe lower back pain 5. liver dysfunction 6. hyperuricemia 7. a recent febrile disease or pneumonia 8. rheumatoid arthritis 9. sickle cell disease-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rate | 18 months |
Secondary
| Measure | Time frame |
|---|---|
| endometrial thickness during IVF treatment | 18 months |
| endometrial thickness | 18 months |
Countries
Israel
Contacts
Primary Contacteinat zivi, MD
Outcome results
None listed