Glaucoma
Conditions
Brief summary
Ocular rigidity characterizes the relationship between pressure and volume changes in the human eye and is expressed as a macroscopic coefficient. Outflow facility is a measure of the resistance of the conventional outflow pathway and represents a parameter that is of interest in glaucoma. Difficulties in the measurement of ocular rigidity in the living human eye have limited our knowledge on this parameter. However, ocular biomechanics have been implicated in the pathogenesis of this disease. The aim of this study is to characterize the pressure volume relation and quantify ocular rigidity and outflow facility in glaucomatous and normal eyes. For this purpose, the investigators have recently developed a manometric method for the measurement of ocular rigidity and outflow facility.
Interventions
PROCEDUREOcular rigidity, outflow facility and intraocular pressure measurement
The measurement procedure includes cannulation of the anterior chamber of the eye, under sterile conditions. Infusion of the eye with microvolumes of a saline solution is performed, followed by manometric measurement of intraocular pressure, in order to quantify ocular rigidity. Outflow facility is estimated from recordings of intraocular pressure after the infusion is stopped.
Sponsors
University of Crete
Larissa University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with primary open or pseudoexfoliation glaucoma that are undergoing cataract surgery * Patients undergoing cataract surgery without evidence of other ocular disease.
Exclusion criteria
* Evidence of any ocular disease, other than specified in the inclusion criteria * Previous ophthalmic surgery or trauma * Significant visual field defect (MD\<-12dB) or an increased cup to disc ratio (\>0.9).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular rigidity coefficient | 2 minutes measurement of ocular rigidity |
| Outflow facility coefficient | 3-4 minutes measurement of outflow facility |
Secondary
| Measure | Time frame |
|---|---|
| Ocular pulse amplitude | 6 minutes |
| Pulsatile ocular blood flow | 6 minutes |
Countries
Greece
Contacts
Primary ContactIoannis Pallikaris, MD
Outcome results
None listed