Exercise Anaphylaxis
Conditions
Keywords
High intensity exercise training, Vascular health, Endothelial function, Circulating angiogenic cells, endothelial progenitor cells, Aerobic capacity, Arterial stiffness, Traditional and emerging cardiovascular disease risk factors
Brief summary
The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women. The long term effects of exercise may be beneficial to cardiovascular health and it is important to understand the training methods that are the most beneficial. In particular we aim to determine if brief maximal exercise improves the function and stiffness of blood vessels and enhance blood vessel repair. Two methods of exercising are being compared, exercise bouts involving intermittent exercise and exercise completed all at once, but at a very high intensity.
Interventions
BEHAVIORALSprint interval exercise
3 session per week of exercise on a exercise cycle ergometer. Each session involves 30s of maximal exercise followed by 4.5 min of easy cycling at 10W. This is repeated 4 times at each exercise session.
BEHAVIORALMaximal continuous exercise
3 sessions per week of an exercise intervention involving maximal cycling until the participant has completed an amount of work equivalent to a sprint interval training session. This exercise lasts between 3 and 3.5 minutes.
Sponsors
University of Leeds
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* Young healthy females * Between 18-25 years old * No on medication (this includes contraceptives)
Exclusion criteria
* Medication use (including oral contraceptives) * Amenorrhoea * High blood pressure * Very active (\>3 hours per week of organized physical activity)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal oxygen uptake | 4 weeks | A measure of aerobic capacity determined during an incremental exercise test to volitional fatigue on an exercise ergometer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability | 4 weeks | — |
| Endothelial progenitor cell function | 4 weeks | measures of in vitro cell migratory ability, adhesion and classification of endothelial progenitor cells |
| Flow mediated dialtion | 4 weeks | Measure of vascular endothelial function determined non-invasively at the brachial artery |
| Arterial stiffness | 4 weeks | The stiffness of the carotid artery is measured using a combination of ultrasound imaging and non-invasive blood pressure measurements. Lower degrees of stiffness are more favourable. |
| Circulating angiogenic cell numbers | 4 weeks | These cells are involved in vascular repair and proliferation and may be measured using flow cytometric methods. Specifically cells with CD34 and CD309 antigens are enumerated. |
Countries
United Kingdom
Contacts
Primary ContactKaren M Birch, BSc PhD
Backup ContactMark Rakobowchuk, BSc MSc PhD
Outcome results
None listed