Anticoagulation
Conditions
Keywords
anticoagulation with ASS, anticoagulation with clopidogrel
Brief summary
Clonidin works as a presynaptic agonist of alpha-sympathomimetic receptors of the brain but also in many other tissues. It is part of balanced anesthesia in general anesthesiology as well as a sedastive agent in intensive care units, but also serves as a third-line agent in many psychiatric diseases including ADHD, schizophrenia and PTSD. The investigators want to show whether clonidin has an procoagulatoric effect on thrombozytes of patients under double anticoagulaotirc treatment with ASS and clopidogrel. The investigators will use a flowcytometric assay to determine activation of thrombozytes when they come into contact with clonidine in vitro as well as Multiplate analyses to determine activation of thrombozytes, either thrombin.induced aggregation, ADP-induced aggregation or arachidonic acid-induced aggregation of thrombozytes.
Interventions
None listed
Sponsors
Goethe University
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Elective vascular surgical patients with long-term medication (at least 5 days) with ASS and clopidogrel * Age above 18 years
Exclusion criteria
* Additional anticoagulatoric treatment woth another inhibitor of platelet aggregation * Surgery within the last two weeks * Patients with long-term mediaction with omeprazole * Patients under hemodialysis * Patients with renal insufficiency (creatinine above 1.5mg/dl, urea above 80mg/dl) * Patients with hepatic dysfunction (GOT above 30U/I, GPT above 30 U/I, GLDH above 10 U/I) * Age under 18 yeary * Non-responder to ASS and / or clopidogrel
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numbers of participants with an activated area under the curve in ASPI test | 30 minutes | Blood of patients under ASS and clopidogrel will show an activated platelet aggregation due to titrated clonidine in ASPI test, i.e. an activated area under the curve in Multiplate analysis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Numbers of participants with an activated area under the curve in TRAP test and ADP test | 30 minutes | Blood of patients under ASS and clopidogrel will show an activated platelet aggregation due to titrated clonidine in TRAP test and ADP test, i.e. an activated area under the curve in Multiplate analysis. |
Countries
Germany
Outcome results
None listed