Nerve Degeneration
Conditions
Keywords
orange juice, cognitive function, flavonoids, flavanones
Brief summary
This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.
Interventions
DIETARY_SUPPLEMENTHigh flavanone orange juice
High flavonone orange juice drink.
DIETARY_SUPPLEMENTControl orange juice
Orange beverage, low flavanone content, matched for total carbohydrate content, individual sugar profile, vitamin C
Sponsors
University of Reading
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
60 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* In good general health i.e. no major health condition such as diabetes * BMI \< 30 * Cholesterol \< 6 and BP \< 150/90 * Not on blood pressure medication or blood thinning medication such as aspirin - No learning difficulty such as dyslexia
Exclusion criteria
* Diabetes * Gastro-intestinal disease * High BMI * Cholesterol and BP * Smoker * On blood pressure medication or blood thinning medication such as aspirin * Dyslexic/dyspraxic * Depression or history of depression
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Executive function - Attention | change in attention from baseline and 8 weeks | Assessment by human cognitive test battery delivered by computer and human operator. Assessments will be carried out at baseline and at the end of each intervention arm. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma flavanones | change from baseline to 8 weeks | By High performance liquid chromatography |
| Blood pressure | change from baseline to 8 weeks | Blood pressure measurement |
Countries
United Kingdom
Outcome results
None listed