Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01311544

Enrollment

Registered

2011-03-09

Start date

2011-03-31

Completion date

Unknown

Last updated

2012-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke, Acute

Brief summary

The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic. An ultra-fast 3D MRA originally developed for the cardiac imaging, k-t blast (Broad-use Linear Acquisition Speed-up Technique) could be used to review the supraaortic vessels. This MRA offers the following advantages: short acquisition time, wide spatial coverage (of the thoracic aorta to the distal encephalic arteries), 3D spatial resolution and high temporal resolution. These qualities are even more optimal with a high magnetic field (3T). The high temporal resolution is interesting because it provides to repeat a volume every eight seconds and thus to have a dynamic evaluation of vascular filling and to assess the vascular supply of the infarcted territory. This sequence is classified as a 4D MRA.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Men and women over 18 years * Eligibility for intravenous thrombolytic treatment (National Institute of Neurological Disorders and Stroke criteria) * Permanent ischemic stroke confirm with encephalic MRI (Magnetic Resonance Imaging) * Patient able of accepting protocol information * Patient who received information about the protocol and had not expressed its opposition to participate

Exclusion criteria

* Pacemaker * Surgical ferromagnetic clips * Cochlear implants * Intraocular metallic foreign body * Iron implants or objects likely to concentrate the Radio Frequency field * Claustrophobia * Known intolerance to contrast media (DOTAREM) * Pregnant women (Beta Human Chorionic gonadotrophin performed for biological assessment of thrombolysis) * Patient with severe kidney with Glomerular Filtration rate \< 30 ml/min * Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Design outcomes

Primary

Measure	Time frame
Images quality for each cervical and intracranial arteries	6 months

Secondary

Measure	Time frame
Quantification of carotid stenosis with NASCET classification	6 months
Study of dynamic vascular consequences of carotid stenosis	6 months

Countries

France

Outcome results