Evaluation of Graft Material in Coronary Artery Bypass Grafting (CABG)

Mid-term Patency of Radial Artery and No Touch Saphenous Vein as Grafts in CABG; A Randomised Controlled Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01310725

Enrollment

108

Registered

2011-03-08

Start date

2004-01-31

Completion date

2010-11-30

Last updated

2011-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angina Pectoris

Keywords

CABG, LIMA, saphenous vein, radial artery

Brief summary

The aim of the study is to evaluate the patency in different kinds of vessels used as graft material in coronary artery bypass grafting. The hypothesis is that vein grafts harvested with a pedicle of surrounding tissue have the same, or better, patency compared to radial grafts and that skeletonisation of the left internal mammary artery does not effect the patency for this graft.

Detailed description

Patients undergoing coronary artery bypass grafting are included in the study. Each patient receive a radial artery graft and a vein graft harvested with a pedicle of surrounding tissue to the right and left side of the heart respectively. The left internal mammary artery is used for the left anterior descending artery in a skeletonised or non-skeletonised fashion. The evaluation is made with angiography up to 5 years after surgery.

Interventions

PROCEDURECoronary artery bypass grafting

Bypass of stenoses in coronary arteries using different types os vessels as conduit.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Isolated coronary artery disease embracing all three main branches of the coronary artery tree.

Exclusion criteria

* Kidney insufficiency (Creatinine \> 120 µmol/L) * War-farin anticoagulation therapy * Ejection fraction \< 40% * Repeat operation * Other concurrent sur-gery * Signs of reduced circulation in non-dominant hand * Other severe illness, or if the patient declines to participate.

Design outcomes

Primary

Measure	Time frame
Functional grafts defined as opened or closed.	Up to 5 years after surgery.

Secondary

Measure	Time frame
Degree of stenosis in implanted grafts.	Up to 5 years after surgery.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026