Prostate Cancer
Conditions
Brief summary
The purpose of this project is to develop and evaluate fluorine-18 (F-18) fluorocholine (FCH) positron emission tomography (PET) as an imaging technique that can be used to delineate malignant tumors in the prostate gland. The proposed technique works by measuring the tissue metabolism of FCH, a substrate that is preferentially metabolized by cancer cells due to malignant over-expression of the choline transporter and choline kinase enzyme. The project scope covers a clinical study to recruit men with prostate cancer who have elected treatment by radical prostatectomy surgery. These men will undergo pre-operative PET scanning to measure F-18 FCH uptake in anatomical sextants of the prostate gland. Imaging results will be compared to histopathologic analyses of the prostatectomy specimen to determine the accuracy of F-18 FCH PET for detecting cancerous prostate sextants.
Interventions
DEVICEFluourine-18 Fluoromethylcholine PET/CT Imaging
Single-dose Study
Sponsors
United States Department of Defense
Queen's Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinically Organ Confined Prostate Cancer Electing Radical Prostatectomy
Exclusion criteria
* Weight \> 300 lb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histopathologic Diagnosis - sextant diagnosis by whole-prostate step section histopathologic analysis | Immediate - no longitudinal data collected |
Countries
United States
Outcome results
None listed