Anemia
Conditions
Brief summary
This observational study will assess the effect of long-term treatment with Mircera (methoxy polyethylene glycol-epoetin beta) in chronic kidney disease patients with renal anemia. Data will be collected from each patient for at least 24 months.
Interventions
None listed
Sponsors
Hoffmann-La Roche
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients, \>/= 18 years of age * Patients with chronic kidney disease (CKD), stages IV and V * Treatment with Mircera according to label
Exclusion criteria
* Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hemoglobin Levels at Monthly Intervals | Prior to Day 1, Months 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24 | Hemoglobin levels were measured as grams/deciliter (g/dL). |
| Percentage of Participants Within Pre-defined Range of Hemoglobin Values | Months 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24 | Percentage of participants with hemoglobin values within the following pre-defined ranges is presented: 11-12 gram/deciliter (g/dL), 10-12 g/dL, 11-13 g/dL, and 10-13 g/dL. |
| Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Months 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24 | Average methoxy polyethylene glycol-epoetin beta dose per application by study month. Mean values were taken when more than 1 application was documented for a participant during the time period considered. |
Countries
Germany
Participant flow
Pre-assignment details
In this non-interventional study, physician was completely free in his/her decision which participants he/she treated with the medication selected in this study, what dosage was chosen, which diagnostic measures were taken, how the course of treatment was monitored and what accompanying or supplemental medications were prescribed.
Participants by arm
| Arm | Count |
|---|---|
| Methoxy Polyethylene Glycol-epoetin Beta Participants received methoxy polyethylene glycol-epoetin beta intravenously or subcutaneously as prescribed by the physician and were observed for 24 months. The actual dose was chosen by the physician and was adjusted as necessary. | 978 |
| Total | 978 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Overall Study | Administrative Problems | 141 |
| Overall Study | Adverse Event | 56 |
| Overall Study | Enrolled but not Treated | 107 |
| Overall Study | Kidney Transplant | 25 |
| Overall Study | Lack of Acceptance | 15 |
| Overall Study | Other | 256 |
| Overall Study | Other Erythropoiesis-stimulating Agents | 119 |
| Overall Study | Study Completion Data Not Recorded | 95 |
| Overall Study | Withdrawal by Subject | 25 |
Baseline characteristics
| Characteristic | Methoxy Polyethylene Glycol-epoetin Beta |
|---|---|
| Age, Continuous | 67.0 years STANDARD_DEVIATION 13.9 |
| Gender Female | 428 Participants |
| Gender Male | 550 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 120 / 978 |
| serious Total, serious adverse events | 172 / 978 |
Outcome results
Primary
Average Methoxy Polyethylene Glycol-epoetin Beta Dose
Average methoxy polyethylene glycol-epoetin beta dose per application by study month. Mean values were taken when more than 1 application was documented for a participant during the time period considered.
Time frame: Months 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24
Population: Effectiveness Population I. N (number of participants analyzed) = participants evaluable for this measure. n = participants with methoxy polyethylene glycol-epoetin beta dose values during study period considered.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 24 (Day 706-735) (n=46) | 116.30 microgram (mcg) | Standard Deviation 88 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 1 (Day 1-45) (n=933) | 103.23 microgram (mcg) | Standard Deviation 68.23 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 2 (Day 46-75) (n=797) | 102.27 microgram (mcg) | Standard Deviation 70.96 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 3 (Day 76-105) (n=785) | 102.48 microgram (mcg) | Standard Deviation 71.23 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 4 (Day 106-135) (n=758) | 102.64 microgram (mcg) | Standard Deviation 70.88 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 5 (Day 136-165) (n=700) | 104.55 microgram (mcg) | Standard Deviation 74.81 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 6 (Day 166-195) (n=673) | 102.87 microgram (mcg) | Standard Deviation 76.01 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 7 (Day 196-225) (n=631) | 101.08 microgram (mcg) | Standard Deviation 77.76 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 8 (Day 226-255) (n=562) | 103.13 microgram (mcg) | Standard Deviation 77.41 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 9 (Day 256-285) (n=509) | 103.31 microgram (mcg) | Standard Deviation 78.43 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 10 (Day 286-315) (n=481) | 104.62 microgram (mcg) | Standard Deviation 77.59 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 11 (Day 316-345) (n=452) | 103.37 microgram (mcg) | Standard Deviation 75.16 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 12 (Day 346-375) (n=396) | 104.88 microgram (mcg) | Standard Deviation 77.43 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 13 (Day 376-405) (n=382) | 103.63 microgram (mcg) | Standard Deviation 79.82 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 14 (Day 406-435) (n=375) | 107.37 microgram (mcg) | Standard Deviation 81.52 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 15 (Day 436-465) (n=328) | 105.49 microgram (mcg) | Standard Deviation 80.5 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 16 (Day 466-495) (n=290) | 113.21 microgram (mcg) | Standard Deviation 82.47 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 17 (Day 496-525) (n=281) | 107.10 microgram (mcg) | Standard Deviation 82.63 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 18 (Day 526-555) (n=262) | 101.96 microgram (mcg) | Standard Deviation 81.36 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 19 (Day 556-585) (n=230) | 107.25 microgram (mcg) | Standard Deviation 80.88 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 20 (Day 586-615) (n=196) | 110.81 microgram (mcg) | Standard Deviation 87.95 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 21 (Day 616-645) (n=201) | 107.80 microgram (mcg) | Standard Deviation 90.14 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 22 (Day 646-675) (n=166) | 109.98 microgram (mcg) | Standard Deviation 88.88 |
| Methoxy Polyethylene Glycol-epoetin Beta | Average Methoxy Polyethylene Glycol-epoetin Beta Dose | Month 23 (Day 676-705) (n=144) | 118.49 microgram (mcg) | Standard Deviation 102.6 |
Primary
Hemoglobin Levels at Monthly Intervals
Hemoglobin levels were measured as grams/deciliter (g/dL).
Time frame: Prior to Day 1, Months 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24
Population: Effectiveness Population I: all participants for whom at least 1 hemoglobin value was documented after the first application of methoxy polyethylene glycol-epoetin beta during the study course. N (number of participants analyzed) = participants evaluable for this measure. n = participants with hemoglobin values during study period considered.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Prior to Day 1 (n=926) | 11.15 g/dL | Standard Deviation 1.21 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 1 (Day 1-45) (n=802) | 11.31 g/dL | Standard Deviation 1.24 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 2 (Day 46-75) (n=715) | 11.33 g/dL | Standard Deviation 1.23 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 3 (Day 76-105) (n=684) | 11.28 g/dL | Standard Deviation 1.32 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 4 (Day 106-135) (n=685) | 11.28 g/dL | Standard Deviation 1.25 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 5 (Day 136-165) (n=602) | 11.25 g/dL | Standard Deviation 1.22 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 6 (Day 166-195) (n=580) | 11.36 g/dL | Standard Deviation 1.27 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 7 (Day 196-225) (n=541) | 11.30 g/dL | Standard Deviation 1.26 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 8 (Day 226-255) (n=516) | 11.31 g/dL | Standard Deviation 1.25 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 9 (Day 256-285) (n=436) | 11.46 g/dL | Standard Deviation 1.28 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 10 (Day 286-315) (n=423) | 11.40 g/dL | Standard Deviation 1.27 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 11 (Day 316-345) (n=402) | 11.44 g/dL | Standard Deviation 1.31 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 12 (Day 346-375) (n=374) | 11.31 g/dL | Standard Deviation 1.27 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 13 (Day 376-405) (n=351) | 11.29 g/dL | Standard Deviation 1.16 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 14 (Day 406-435) (n=344) | 11.26 g/dL | Standard Deviation 1.16 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 15 (Day 436-465) (n=304) | 11.30 g/dL | Standard Deviation 1.2 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 16 (Day 466-495) (n=272) | 11.37 g/dL | Standard Deviation 1.19 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 17 (Day 496-525) (n=265) | 11.34 g/dL | Standard Deviation 1.27 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 18 (Day 526-555) (n=226) | 11.36 g/dL | Standard Deviation 1.13 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 19 (Day 556-585) (n=213) | 11.28 g/dL | Standard Deviation 1.22 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 20 (Day 586-615) (n=187) | 11.16 g/dL | Standard Deviation 1.16 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 21 (Day 616-645) (n=186) | 11.23 g/dL | Standard Deviation 1.16 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 22 (Day 646-675) (n=167) | 11.38 g/dL | Standard Deviation 1.21 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 23 (Day 676-705) (n=143) | 11.34 g/dL | Standard Deviation 1.13 |
| Methoxy Polyethylene Glycol-epoetin Beta | Hemoglobin Levels at Monthly Intervals | Month 24 (Day 706-735) (n=37) | 11.66 g/dL | Standard Deviation 1.23 |
Primary
Percentage of Participants Within Pre-defined Range of Hemoglobin Values
Percentage of participants with hemoglobin values within the following pre-defined ranges is presented: 11-12 gram/deciliter (g/dL), 10-12 g/dL, 11-13 g/dL, and 10-13 g/dL.
Time frame: Months 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24
Population: Effectiveness Population I. N (number of participants analyzed) = participants evaluable for this measure. n = participants with hemoglobin values during study period considered.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 1 (Day 1-45) (n=802) | 37.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 1 (Day 1-45) (n=802) | 61.6 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 1 (Day 1-45) (n=802) | 56.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 1 (Day 1-45) (n=802) | 80.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 2 (Day 46-75) (n=715) | 39.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 2 (Day 46-75) (n=715) | 62.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 2 (Day 46-75) (n=715) | 58.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 2 (Day 46-75) (n=715) | 81.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 3 (Day 76-105) (n=684) | 33.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 3 (Day 76-105) (n=684) | 58.3 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 3 (Day 76-105) (n=684) | 53.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 3 (Day 76-105) (n=684) | 77.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 4 (Day 106-135) (n=685) | 35.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 4 (Day 106-135) (n=685) | 62.6 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 4 (Day 106-135) (n=685) | 53.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 4 (Day 106-135) (n=685) | 81.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 5 (Day 136-165) (n=602) | 36.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 5 (Day 136-165) (n=602) | 65.3 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 5 (Day 136-165) (n=602) | 53.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 5 (Day 136-165) (n=602) | 82.6 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 6 (Day 166-195) (n=580) | 41.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 6 (Day 166-195) (n=580) | 64.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 6 (Day 166-195) (n=580) | 57.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 6 (Day 166-195) (n=580) | 80.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 7 (Day 196-225) (n=541) | 39.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 7 (Day 196-225) (n=541) | 62.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 7 (Day 196-225) (n=541) | 56.6 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 7 (Day 196-225) (n=541) | 80.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 8 (Day 226-255) (n=516) | 37.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 8 (Day 226-255) (n=516) | 60.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 8 (Day 226-255) (n=516) | 56.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 8 (Day 226-255) (n=516) | 79.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 9 (Day 256-285) (n=436) | 38.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 9 (Day 256-285) (n=436) | 58.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 9 (Day 256-285) (n=436) | 58.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 9 (Day 256-285) (n=436) | 78.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 10 (Day 286-315) (n=423) | 39.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 10 (Day 286-315) (n=423) | 60.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 10 (Day 286-315) (n=423) | 59.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 10 (Day 286-315) (n=423) | 80.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 11 (Day 316-345) (n=402) | 38.3 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 11 (Day 316-345) (n=402) | 61.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 11 (Day 316-345) (n=402) | 57.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 11 (Day 316-345) (n=402) | 80.6 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 12 (Day 346-375) (n=374) | 36.6 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 12 (Day 346-375) (n=374) | 60.7 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 12 (Day 346-375) (n=374) | 54.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 12 (Day 346-375) (n=374) | 78.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 13 (Day 376-405) (n=351) | 37.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 13 (Day 376-405) (n=351) | 63.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 13 (Day 376-405) (n=351) | 57.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 13 (Day 376-405) (n=351) | 82.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 14 (Day 406-435) (n=344) | 35.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 14 (Day 406-435) (n=344) | 64.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 14 (Day 406-435) (n=344) | 54.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 14 (Day 406-435) (n=344) | 83.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 15 (Day 436-465) (n=304) | 36.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 15 (Day 436-465) (n=304) | 64.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 15 (Day 436-465) (n=304) | 54.3 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 15 (Day 436-465) (n=304) | 82.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 16 (Day 466-495) (n=272) | 34.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 16 (Day 466-495) (n=272) | 64.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 16 (Day 466-495) (n=272) | 54.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 16 (Day 466-495) (n=272) | 83.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 17 (Day 496-525) (n=265) | 35.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 17 (Day 496-525) (n=265) | 64.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 17 (Day 496-525) (n=265) | 52.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 17 (Day 496-525) (n=265) | 80.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 18 (Day 526-555) (n=226) | 41.6 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 18 (Day 526-555) (n=226) | 67.3 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 18 (Day 526-555) (n=226) | 57.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 18 (Day 526-555) (n=226) | 83.2 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 19 (Day 556-585) (n=213) | 37.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 19 (Day 556-585) (n=213) | 62.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 19 (Day 556-585) (n=213) | 54.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 19 (Day 556-585) (n=213) | 79.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 20 (Day 586-615) (n=187) | 36.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 20 (Day 586-615) (n=187) | 62.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 20 (Day 586-615) (n=187) | 54.0 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 20 (Day 586-615) (n=187) | 79.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 21 (Day 616-645) (n=186) | 37.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 21 (Day 616-645) (n=186) | 63.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 21 (Day 616-645) (n=186) | 55.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 21 (Day 616-645) (n=186) | 81.7 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 22 (Day 646-675) (n=167) | 47.9 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 22 (Day 646-675) (n=167) | 68.3 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 22 (Day 646-675) (n=167) | 63.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 22 (Day 646-675) (n=167) | 83.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 23 (Day 676-705) (n=143) | 30.8 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 23 (Day 676-705) (n=143) | 61.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 23 (Day 676-705) (n=143) | 54.5 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 23 (Day 676-705) (n=143) | 85.3 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-12 g/dL: Month 24 (Day 706-735) (n=37) | 35.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-12 g/dL: Month 24 (Day 706-735) (n=37) | 54.1 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 11-13 g/dL: Month 24 (Day 706-735) (n=37) | 51.4 percentage of participants |
| Methoxy Polyethylene Glycol-epoetin Beta | Percentage of Participants Within Pre-defined Range of Hemoglobin Values | 10-13 g/dL: Month 24 (Day 706-735) (n=37) | 70.3 percentage of participants |