Prehypertension
Conditions
Keywords
Prehypertension, Flow mediated dilation, Pulse wave velocity, carotid compliance, Prehypertension and amiloride
Brief summary
Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of young adults with prehypertension.
Interventions
DRUGAmiloride
Amiloride 10 mg orally once a day for 16 weeks
Sponsors
Augusta University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP between 80 to 89 mmHg during screening visit. BP will be measured manually tree times at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair. The average of last two BP measurements will be taken into consideration. * Male or female of Caucasian or African-American origin. * No history of any major past and current medical illness (such as diabetes, renal disease, liver disease etc.) * Not taking any medication that affects blood pressure.
Exclusion criteria
* HbA1C \> 7.0 % during screening visit. * Serum potassium \> 5.5 mEq/L during screening and/or any testing visit due to risk of developing hyperkalemia. * Serum creatinine \> 1.5 mg/100 ml and/or creatinine clearance \< 50 ml/min\* (Glomerular Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or any testing visit due to risk of developing renal dysfunction. * Female having positive pregnancy test during screening and/or any testing visit.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular phenotypes | 16 weeks | (Flow mediated dilation, Pulse wave velocity, and carotid artery compliance) |
Countries
United States
Contacts
Primary ContactSamip J Parikh, MBBS, MPH
Outcome results
None listed