Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01308320

Enrollment

Registered

2011-03-04

Start date

2010-02-28

Completion date

2010-07-31

Last updated

2011-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Neoplasm

Brief summary

Fentanyl is expected to suppress tracheal tube-induced cough during emergence from general anaesthesia through binding to its receptors in the brainstem. However, it has not been proven if fentanyl has a complication-free, dose-dependent effect on cough suppression during emergence from sevoflurane anaesthesia. The purpose of this study is to evaluate the relationship between fentanyl doses and cough suppression during emergence from sevoflurane anaesthesia.

Interventions

DRUGfentanyl citrate

According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.

DRUGsaline

According to the enrolled group, certain dose of saline is intravenously administered by bolus just after sevoflurane discontinuation.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 59 Years

Healthy volunteers

Inclusion criteria

* the patients undergoing general anaesthesia for elective thyroidectomy due to thyroid neoplasm. * ASA I-II. * 20-59 years old. * female only.

Exclusion criteria

* signs of difficult intubation. * risks for perioperative pulmonary aspiration. * history of chronic respiratory disease. * recent upper respiratory track infection. * previous and recent smoking history

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026