Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery

Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01308138

Acronym

TRIMRIPC

Enrollment

Registered

2011-03-03

Start date

2011-01-31

Completion date

2013-07-31

Last updated

2015-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Injury

Keywords

Physical Activity, pathology, Physical Deconditioning

Brief summary

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Interventions

BEHAVIORALExercise training

exercise training

PROCEDUREremote ischemic preconditioning

remote ischemic preconditioning

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients undergoing coronary heart surgery and heart transplantation

Exclusion criteria

* myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin \> 140)

Design outcomes

Primary

Measure	Time frame	Description
Mitochondrial respiration	1 hour	Oxygraph (Strathkelvin)

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 19, 2026