Continuous Hemodialysis
Conditions
Brief summary
The investigators aim to show, whether all middle molecules are included in the clearance and whether this clearance is stable until 72 hours.
Detailed description
A better middle molecule clearance has been shown until 24 hours of duration. The investigators will extend our observations until 72 hours.
Interventions
DEVICEHemodialysis with EMIC 2 filters
Patients with indication for routine continuous hemodialysis due to acute renal insufficiency
Sponsors
Fresenius Medical Care Deutschland GmbH
Klinik für Anästhesiologie
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* informed consent * age\>18 years * acute renal insufficiency with indication for continuous hemodialysis, according to RILFE classification F: serum creatinine increase \> 3-fold or serum creatinine \> 4mg/dl with acute increase of \>0,5mg/dl Urine Output \<0,3mg/kg/h for 24 h or anuria for 12 h * body weight:60-80kg * anticoagulation with citrate possible and indicated * Dose for hemodialysis of 2l/h
Exclusion criteria
* participation in another clinical trial within on month prior to this study * pregnancy or brest feeding * septic shock * interference with cystatin-C 1. haemolysis \<1g/dl 2. Bilirubin\<9mg/dl 3. Triglyceride \>700mg/dl 4. rheumatoid factor \> 300kIU/l
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clearance of albumin | up to 72 h |
| Clearance of Beta2-Microglobulin | up to 72 h |
| Clearance of Osteocalcin | up to 72 h |
| Free light chains kappa of Immunoglobulins | up to 72 h |
| Clearance of Urea | up to 72 h |
| Clearance of Cystatin C | up to 72 h |
| Clearance of creatinine | up to 72 h |
Secondary
| Measure | Time frame |
|---|---|
| Vasopressor requirement | up to 72 h |
| Heart rate | up to 72 h |
| Mean arterial pressure | up to 72 h |
Countries
Germany
Outcome results
None listed