Underdosing of Local Anesthetics, Initial Encounter
Conditions
Keywords
liposomes, ropivacaine, dental anesthesia, dentistry
Brief summary
This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated ropivacaine formulation for dental anesthesia.
Detailed description
This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated 0, 5% ropivacaine for dental anesthesia after maxillary infiltration.
Interventions
DRUGRopivacaine
1,8 mL of the local anesthetic formulations were injected at the apex of the maxillary right canine.
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
University of Campinas, Brazil
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy
Exclusion criteria
* Volunteers were free from cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and haematological diseases, psychiatric disorders and allergy to local anesthetics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| After anesthetic injection the pulpal response was assessed by an electrical pulp tester. | 100 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Duration of soft tissue anesthesia was measured as the time from beginning to end of lip and gingival numbness. | 240 minutes |
Countries
Brazil
Outcome results
None listed