Lung Neoplasms
Conditions
Keywords
remote ischemic preconditioning, lung injury, pulmonary resection
Brief summary
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.
Detailed description
Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary resection, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.
Interventions
PROCEDUREremote ischemic preconditioning
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated.
Sponsors
Cai Li
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of pulmonary carcinoma * Must be received pulmonary lobectomy
Exclusion criteria
* Cardiac disease categorized as NYHA classes II-IV * Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2) \<60 mmHg or FEV1\<50% predicted), * Pre-existing coagulopathy or thrombocytopenia * Prior receipt of chemotherapy or radiation therapy or immunotherapy * Systemic or local active infections (either clinically defined or suggested by evidence such as elevated C-reactive protein levels, leukocytosis, or a body temperature\>38℃) * Peripheral vascular disease affecting the upper limbs * Administration of vitamins, nonsteroidal anti-inflammatory agent or corticosteroid within 3 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy | June,2013 | PaO2/FiO2 in the limb RIPC group was significantly higher than that in the control group at 30 and 60 min after OLV, 30 min and 6 h after operation (all P\<0.05) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cs and Cd | June,2013 | Cs and Cd in limb RIPC group were significantly higher than those in the control group at 30 and 60 min after OLV (all P\<0.05) |
| IL-6 and TNF-α | June,2013 | The IL-6 levels in the limb RIPC group were lower than those in the control group at 30 min, 6, 12, 24 and 48 h after operation (all P\<0.05), and there was a significant difference in TNF-α level between the groups (P\<0.01). |
Countries
China
Outcome results
None listed