Parkinson's Disease
Conditions
Keywords
deep brain stimulation, subthalamic nucleus
Brief summary
Stimulation of the subthalamic nucleus will have effects on various aspects of neuropsychiatric function.
Interventions
Stimulation is delivered to the subthalamic nucleus at experimentally prescribed settings.
Sponsors
National Alliance for Research on Schizophrenia and Depression
University of California, San Diego
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants diagnosed with idiopathic Parkinson's disease that meet criteria for treatment of their disease with STN-DBS. Participants will be selected for this study without regard for age (provided they are older than 18), gender or ethnic background. * Participants must have undergone subthalamic nucleus DBS surgery and be receiving treatment at the Scripps Clinic in La Jolla, CA
Exclusion criteria
* Patients under 18 years old. * Patients with mini-mental status scores below 26/30. * Patients with known psychiatric disease. * Patients who are too infirm, demented or dysarthric to clearly understand the consenting process, task instructions, or to communicate verbally regarding participation or non-participation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| behavioral task performance | 1 to 2 hours | Participants will complete behavioral tasks at each of three visits to assess the effects of stimulation settings on task performance. At each research visit, behavior will be assessed beginning at 1 hour after the stimulation is adjusted to the experimental settings. Stimulation settings will be returned to each patient's treatment levels at the culmination of each visit. |
Countries
United States
Outcome results
None listed