Relationship Between Obstructive Sleep Apnea and Coronary Atherosclerosis

Intravascular Ultrasound Diagnostic Evaluation of Atherosclerosis in Singapore- Obstructive Sleep Apnea (IDEAS-OSA) Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01306526

Acronym

IDEAS-OSA

Enrollment

118

Registered

2011-03-02

Start date

2011-02-28

Completion date

2013-03-31

Last updated

2014-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Obstructive Sleep Apnea

Keywords

Thin-cap fibroatheroma, Vulnerable plaque, Coronary artery disease, Obstructive sleep apnea, Intravascular Ultrasound

Brief summary

Obstructive sleep apnea (OSA) is a respiratory disorder of sleep characterized by recurrent episodes of complete or partial upper airway obstruction, leading to intermittent oxygen deprivation. This results in sympathetic activation and surges in blood pressure, production of vasoactive substances, as well as activation of the inflammatory and procoagulant pathways. Epidemiological evidence indicates the prevalence of OSA is higher in patients with coronary artery disease than in the general population. The investigators recently showed that 65.7% and 41.9% of the Singapore patients admitted with myocardial infarction were found to have previously undiagnosed OSA and severe OSA, respectively. In a 10-year follow-up epidemiological study, OSA was independently associated with a higher prevalence of fatal and non-fatal cardiovascular events among the otherwise healthy general population. The investigators further showed that in patients who have undergone primary percutaneous coronary intervention for acute myocardial infarction, OSA was an independent predictor of future adverse event rates. Despite the observed association between OSA and adverse cardiovascular outcomes, the underlying pathophysiological mechanisms remain unclear. In this proposal, the investigators aim to elucidate the relationship between OSA and composition of coronary atherosclerotic plaques.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

21 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Angiogrqaphically documented coronary artery disease * De novo lesion * Native coronary artery

Exclusion criteria

* known OSA * intubation and mechanical ventilation * electrical instability with a high risk of malignant ventricular arrhythmia * cardiogenic shock * previous coronary artery bypass surgery * chronic renal failure on dialysis * inability to give informed consent

Design outcomes

Primary

Measure	Time frame	Description
Total Atheroma Volume	Baseline	Relationship between OSA and Total Atheroma Volume determined (IVUS) will be determined

Secondary

Measure	Time frame	Description
Thin-cap fibroatheroma	Baseline	Relation between OSA and prevalence of thin-cap fibroatheroma (VH-IVUS) will be determined

Countries

Singapore

Outcome results