Natural History of Mineral Metabolism Parameters and Protein-bound Toxins in Incident Peritoneal Dialysis Patients

Natural History of Biochemical Parameters of Mineral Metabolism and Protein-bound Uremic Retention Molecules in Incident Peritoneal Dialysis Patients: a Longitudinal Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01306149

Enrollment

Registered

2011-03-01

Start date

2002-07-31

Completion date

2017-01-31

Last updated

2017-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complication of Peritoneal Dialysis

Keywords

biochemical parameters, mineral metabolism, protein-bound uremic retention solutes, incident PD patients

Brief summary

The aims of this study are 1. To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules', and protein bound URM in incident peritoneal dialysis (PD) patients. 2. To evaluate the natural history and determinants of the generation rate of URM originating from bacterial protein fermentation in PD patients. 3. To evaluate the natural history of biochemical parameters of mineral metabolism in incident PD patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Incident PD patients, defined as patients who started on PD as first renal replacement therapy less than 8 weeks before inclusion * written informed consent * age \> 18 years old

Design outcomes

Primary

Measure	Time frame	Description
natural history of clearances and serum parameters of mineral metabolism and protein-bound toxins	15 years	To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules, and protein bound URM in incident peritoneal dialysis (PD) patients.

Secondary

Measure	Time frame	Description
determinants of generation rate of uremic retention solutes	15 years on average	To evaluate the natural history and determinants of the generation rate of URM originating from bacterial protein fermentation in PD patients.

Countries

Belgium

Outcome results