Chronic Obstructive Pulmonary Disease, Emphysema
Conditions
Keywords
COPD, Emphysema phenotype
Brief summary
Chronic Obstructive Pulmonary Disease has two heterogeneous conditions (chronic bronchitis and pulmonary emphysema phenotypes) with a different clinical presentation. The phenotype evaluation in COPD patient (trough clinical, functional and radiographic parameters) could influence final results in pharmacologic and non-pharmacologic management of the disease. The aim of our study is to investigate whether COPD patients with different disease phenotype (chronic bronchitis versus pulmonary emphysema) have a different response to PR.
Interventions
None listed
Sponsors
Villa Pineta Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* COPD disease with any functional grade * Adherence to participate to a pulmonary rehabilitation program
Exclusion criteria
* Recent acute exacerbation (4 weeks preceding enrollment) * Acute severe concomitant cardiovascular diseases * Concomitant neoplastic diseases * NO-Adherence to participate to a pulmonary rehabilitation program
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise tolerance | [Time Frame: Day 1 and 20 ] | Change in Six minute walked distance (6MWD) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dyspnoea | [ Time Frame: Day 1 and 20] | Change in dyspnea grade by MRC |
| Symptoms on effort | [ Time Frame: Day 1 and 20] | Change in Dyspnoea and leg fatigue by Borg scale |
| Perceived Quality of life | [ Time Frame: Day 1 and 20] | Change in Saint George Respiratory Questionnarie (Italian version) |
| Global function | [ Time Frame: Day 1 and 20] | Change in the multidimensional BODE index (validated in COPD population) |
Countries
Italy
Outcome results
None listed