Postnatal Growth Disorder
Conditions
Keywords
Postnatal development, Breast milk fortification, Composition of breast milk
Brief summary
To analyze the weight gain of very low birth weight infants during a minimum period of three weeks before 36 weeks postmenstrual age when infants are fed with breast milk that has been individually fortified.
Interventions
DIETARY_SUPPLEMENTIndividualized fortification of breast milk
Lactose, fat and protein content will be measured prior to breast milk fortification. Subsequently, breast milk for preterm infants will individually fortified adjusted by using data from milk analysis.
Sponsors
McMaster Children's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 32 Weeks
Healthy volunteers
No
Inclusion criteria
* Birth weight ≤ 1500g and gestational age \< 32weeks * Tolerating an enteral intake of ≥ 100 ml/kg/d for ≥ 24h
Exclusion criteria
* Infants fed more than 25% of mean caloric intake for a consecutive week with formula milk * gastrointestinal malformation, major congenital anomalies and chromosomal abnormalities * Babies with enterostoma or short gut syndrome * Fluid restriction below * Renal disease * Sepsis * Necrotizing enterocolitis * Hepatic dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| growth | from inclusion at postmentrual age <32 weeks until 36 weeks | weight gain will be accessed three times per week |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| enteral energy intake | from inclusion at postmentrual age <32 weeks until 36 weeks | caloric intake by enteral feeding will be assesed daily |
| growth, tolerance, morbidity | from inclusion at postmentrual age <32 weeks until 36 weeks | gains in length and head circumference will be assessed weekly, tolerance and morbidity throughout study |
Countries
Canada
Outcome results
None listed