Dry Skin
Conditions
Keywords
dry skin condition
Brief summary
The effects of topically applied pyridoxine tri-isopalmitate (P-IP) which stimulates filaggrin synthesis in keratinocytes, on skin hydration and barrier function were examined. Subjects were separated into two groups to examine the effect of P-IP. Subjects were treated with P-IP formulation on one side of the face and with a placebo formulation on the other side twice daily (morning and evening) for 28 days. All subjects gave written informed consent prior to the study. The skin hydration and TEWL (transepidermal water loss) were evaluated by measuring skin surface conductance with a skin hygrometer SKICON 200EX (I.B.S. ltd., Japan) and TEWL meter AS-CT1 (ASAHI BIOMED, Tokyo, Japan), respectively.
Detailed description
It is expected that the long-term application of P-IP increase skin surface water contents and suppress TEWL.
Interventions
OTHERPyridoxine tri-isopalmitate
2% dosage, oil-in-water emulsion, twice a day, 28 days
Sponsors
University of Dundee
Cosmos Technical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
33 Years to 62 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy skin
Exclusion criteria
* don't use any moisturizer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of skin surface water content and Trans-Epidermal Water Loss (TEWL) | Before application, 1 week, 2 week and 4 weeks after application | Subjects were treated with P-IP formulation on one side of the face and with a placebo formulation (without P-IP, oil-in-water emulsion type) on the other side twice daily (morning and evening) for 28 days. Skin surface water contents and TEWLs were measured at the time frame described above and the results were analyzed as a change from a value of before-application at each measurement. |
Countries
Japan
Outcome results
None listed