Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

Effects of Leucine and Branched-chain Amino Acids (BCAA) Supplementation on Resistance Exercise-induced Muscle Damage and Inflammation: a Randomized, Double-blind, and Placebo-controlled Study

Status

Suspended

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01305018

Enrollment

Registered

2011-02-28

Start date

2011-08-31

Completion date

2012-08-31

Last updated

2011-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Muscle Damage

Keywords

Branched-chain amino acids, Leucine, Muscle damage, Inflammation, supplementation, resistance exercise-induced

Brief summary

This study aims to evaluate the effects of branched-chain amino acids (BCAA) supplementation on resistance exercise-induced muscle damage and inflammation.

Interventions

DIETARY_SUPPLEMENTBCAA

7 g of leucine + 3,5 g of isoleucine + 3,5 g of valine per day during 9 days

DIETARY_SUPPLEMENTLeucine

7 g of leucine + 7 g of alanine per day during 9 days

DIETARY_SUPPLEMENTPlacebo

14 g of alanine per day during 9 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Sedentary; * No muscle disorders; * Must be able to swallow tablets

Design outcomes

Primary

Measure	Time frame
Muscle maximal strength	4 days
Muscle edema	4 days
Muscle soreness	4 days

Secondary

Measure	Time frame	Description
Muscle inflammation	4 days	Immunohistochemistry, protein expression.
Muscle damage	4 days	Serum creatine kinase

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026