Juvenile Idiopathic Arthritis, Oligoarthritis, Polyarticular Juvenile Rheumatoid Arthritis, Systemic Juvenile Idiopathic Arthritis
Conditions
Keywords
Juvenile idiopathic arthritis, Ultrasonography, Cartilage, Cartilage biomarkers, Bone biomarkers
Brief summary
The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.
Interventions
DEVICEUltrasonography
Scanning 5 joints bilaterally with an ultrasound scanner
Sponsors
Aarhus University Hospital
University of Aarhus
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
5 Years to 15 Years
Healthy volunteers
No
Inclusion criteria
* Juvenile idiopathic arthritis: Oligoarticular, polyarticular or systemic onset type. * Informed consent from parents * between 5-15 years of age
Exclusion criteria
* Other diagnoses that involves bones or cartilage * Intraarticular steroid injections within 1 month of the trial investigation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Joint cartilage thickness | 1.5 years | Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of different biomarkers in serum and urine | 1.5 years | Level of bone- and cartilage-degradation biomarkers in serum and urine. COMP, CTX-II, RANKL/OPG, PYD/DPD |
Countries
Denmark
Outcome results
None listed