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Development and Evaluation of a Cognitive Rehabilitation Program for Persons With Multiple Sclerosis

Development and Evaluation of a Cognitive Rehabilitation Program for Persons With Multiple Sclerosis

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01303770
Enrollment
50
Registered
2011-02-25
Start date
2011-02-28
Completion date
2014-12-31
Last updated
2013-12-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Multiple Sclerosis

Keywords

Multiple Sclerosis, Cognitive impairment, Self-management programs, Occupational Therapy, Rehabilitation

Brief summary

Multiple sclerosis (MS) is a progressive neurological disease that affects over 2.5 million people worldwide. Up to 50% of persons with MS (PwMS) will experience some form of cognitive impairment as a result of the disease including disturbances in memory, attention, concentration, information processing, and executive functions such as problem solving, and self-monitoring. MS-related cognitive impairments negatively affect many aspects of functioning and independent participation in everyday life. Thus, PwMS who experience cognitive impairments face a wide array of recurring barriers that pose grave challenges to carrying out everyday activities while trying to maintain multiple life roles and as they age. Management of cognitive symptoms can be addressed through rehabilitation which has the potential to reduce disability, prevent complications of the disease, and enhance participation, independence, and quality of life. Considering the high frequency of cognitive impairments in MS and their significant, complex impact on functioning and independence, it is critical that cognitive interventions be an essential component of MS rehabilitation. The overarching goal of this study is to develop and test a self-management, group-based cognitive rehabilitation program designed specifically for PwMS.

Interventions

BEHAVIORALSelf-management cognitive rehabilitation group intervention

8-week cognitive rehabilitation program facilitated by an occupational therapist. Program goals include increased knowledge of cognitive impairments in multiple sclerosis, increased self-efficacy to manage cognitive changes and increased use of cognitive compensatory strategies.

BEHAVIORALControl intervention

8-week group program that is not specifically directed to management of cognitive impairments.

Sponsors

Tel Aviv University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Diagnosis of MS * 18 years of age or older * Self-report of cognitive difficulties

Exclusion criteria

* Exacerbation of symptoms in past 3 months * History of TBI, CVA, epilepsy, Psychiatric condition, drug/alcohol abuse

Design outcomes

Primary

MeasureTime frame
Cognitive strategy usepre intervention, post intervention, 3,6,12 month followup

Secondary

MeasureTime frame
Cognitive self-efficacypre-intervention, post intervention, 3,6,12 month followup

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026