Effect of Growth Hormone (GH) on Cardiac Echos in GH Deficient Patients After Acromegaly Treatment

Effects of Physiologic Growth Hormone Administration on Echocardiographic Parameters in Subjects With Growth Hormone Deficiency Following Cure of Acromegaly

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01302652

Enrollment

Registered

2011-02-24

Start date

2011-02-28

Completion date

2015-02-28

Last updated

2015-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acromegaly

Keywords

acromegaly, growth hormone, growth hormone deficiency

Brief summary

The purpose of this research study is to study the effects of growth hormone (GH) replacement on the heart. The investigators will study these effects in people who have been cured of acromegaly and then have developed growth hormone deficiency (GHD, not enough growth hormone).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* age 18-75 * history of acromegaly with biochemical cure * growth hormone deficiency

Exclusion criteria

* untreated thyroid disease within the past 3 months * untreated adrenal insufficiency within the past 3 months * uncontrolled hypertension * congestive heart failure * gonadal steroid therapy within the past 3 months * pregnancy or nursing

Design outcomes

Primary

Measure	Time frame
Change from Baseline in Echocardiographic Findings at One Year	baseline and one year

Countries

United States

Outcome results