Nonsmall Cell Lung Cancer
Conditions
Keywords
Asymptomatic brain metastasis, NSCLC, GKS
Brief summary
The need of radiosurgery is controversial for asymptomatic oligo brain metastasis for non small cell lung cancer (NSCLC). Therefore, the investigators do a randomized study comparing overall survival between two groups with or without radiosurgery for asymptomatic oligo brain metastasis before palliative chemotherapy for NSCLC.
Interventions
RADIATIONRadiosurgery
Gamma knife surgery for asymptomatic oligo-metastasis to brain from NSCLC
RADIATIONObservation
No local treatment
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Histologically confirmed non-small cell lung cancer with synchronous brain metastases 2. One to 4 intraparenchymal brain metastases by contrast-enhanced MRI, meeting the following criteria: * Well circumscribed tumor(s) with brain edema Grade 0-1 * Maximum diameter ≤ 3.0 cm 3. No prior surgical treatment or RT for brain metastases 4. No leptomeningeal metastases by MRI or cerebrospinal fluid evaluation 5. Patients without any symptoms or signs from brain metastases (RTOG neurologic functions status of 0) 6. Age, 18 and over 7. ECOG performance status 0-1 8. Written informed consent
Exclusion criteria
1. severe co-morbid illness and/or active infections 2. pregnant or lactating women 3. RTOG neurologic function status of 1\ 4 4. Uncontrollable extracranial metastases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival | 1 year after the enrollment of the last patient |
Secondary
| Measure | Time frame |
|---|---|
| Time to CNS progression | 1 year after the enrollment of the last patient |
Countries
South Korea
Contacts
Primary ContactMyung-Ju Ahn, Pf
Outcome results
None listed