Diabetes
Conditions
Brief summary
Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Asia, especially in Taiwan. Recent studies have shown the hypoglycemic effects of Chlorella through increasing glucose uptake in the liver and muscle, lowering serum free fatty acid levels, or activation of PPAR gamma receptor. However, the hypoglycemic effect in diabetic patients have not been studied. In order to clarify the hypoglycemic effects and mechanism of Chlorella in diabetic patients, the investigators conducted a 12-week randomized, double-blind, placebo-control trial on diabetic patients.
Interventions
DRUGChlorella
Sponsors
Tri-Service General Hospital
Cardinal Tien Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 18-70 years old * type 2 diabetes with less than 2 kinds of oral antidiabetes drugs * Hba1c: 7.0-9.0
Exclusion criteria
* type 1 diabetes * pregnancy * acute infectious disease * autoimmune disease * hemodynamic unstable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c | 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin concentration during oral glucose tolerance test | 12 weeks | All subjects received the first oral glucose tolerance test before intervention(week 0), and the second oral glucose tolerance test on week 12. |
Countries
Taiwan
Contacts
Primary ContactFone-Ching Hsiao, MD
Outcome results
None listed