Early Cardiac Toxicity of Adjuvant CT in Elderly BC.

Inclusion criteria

1. Patient selection criteria * Female aged equal or more than 65 years. * Histological diagnosis of early BC for which the treating physician considers (neo) adjuvant chemotherapy to be beneficial. Recommended situations are: * Triple negative BC if pT \> 1cm. * HER-2 positive BC if pT1 \> 1cm; and trastuzumab will be given after study chemotherapy. * Luminal B cancers defined as ER+, PgR + or neg, Ki-67 ≥ 14%, and pT1 \> 1cm. * Luminal A cancers (ER+, PgR+ and Ki-67 \< 14%) will be considered only if ≥ 4 nodes. * Poor response to a preoperative endocrine therapy. * WHO performance status equal or less than 1. * Baseline LVEF equal or more than 50% measured by echocardiography. * Adequate organ function including: * neutrophils more or equal to 1.5 x 109/L. * platelets more or equal to100 x 109/L. * bilirubin \< 1.25 x upper limit of normal (ULN) for the institution. * transaminases: AST \< 2.5 x ULN , ALT \< 2.5 x ULN and alkaline phosphatase ≤ 2.5 x ULN for the institution. * Estimated creatinine clearance \> 30ml/min (using the Crockoft and Gault formula) (See Appendix E) . * No previous exposure to chemotherapy in this neoadjuvant or adjuvant setting. * No serious cardiac illness or medical conditions as judged by the investigator including, but not confined to:Symptomatic ventricular arrhythmias,Clinical and/or ECG evidence of myocardial infarction within the last 12 months,Coronary artery disease requiring medication,High-risk uncontrolled arrhythmias,Poorly controlled hypertension (e.g. systolic \>180 mm Hg or diastolic \>100 mm Hg). * Other concurrent serious diseases that may interfere with planned treatment including severe pulmonary conditions/illness. * No participation to other clinical trials involving therapeutic agents within the 6 weeks prior to the randomization. * No prior or concurrent diagnosis of cancer, except for adequately treated basocellular and squamous cell carcinoma of the skin or cervical uterine in situ tumor * Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial. * Signed written informed consent must be given according to ICH-GCP and national/local regulations, prior to any study specific screening procedures and randomization. 2. Caregiver selection criteria * to be identified by participating patients as their primary caregivers i.e the person who helps them the most to cope with cancer in their everyday life * to be at least eighteen years old * to be aware of the cancer diagnosis of the patients to be fit enough to complete the questionnaires * to be French speaking * to be free of any cognitive dysfunction. * to give their written informed consent as regards participation in the study.