Effectiveness of Dextrose Injection for Osgood-Schlatter Disease

Phase 2 Study of Dextrose Injection for Sport-Limiting Osgood Schlatter Disease in Adolescents.

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01300754

Enrollment

Registered

2011-02-23

Start date

2006-01-31

Completion date

2010-09-30

Last updated

2011-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osgood-Schlatter Disease

Keywords

Osgood-Schlatter, Tendinosis, Apophysitis, Enthesopathy, Dextrose.

Brief summary

Objective: To examine the potential of dextrose injection versus lidocaine injection versus supervised usual care to change pain/function/activity levels in adolescent athletes with Osgood-Schlatter Disease (OSD).

Detailed description

Patients and methods: Girls ages 9-15 years old and boys ages 10-17 years old will be assigned to either therapist-supervised usual care, or to double-blind injection of 1% lidocaine solution with or without 12.5% dextrose. Injections will be administered monthly for three months. All subjects will then be offered dextrose injections monthly as needed. Change in the Nirschl Pain Phase Scale (NPPS) will serve as the primary outcome measure.

Interventions

PROCEDUREDextrose Injection

12.5 Dextrose in 1% Lidocaine injected monthly for 3 months with a 27 gauge needle on painful areas of the tibial tuberosity, under the patellar tendon.

PROCEDURELidocaine Injection

1% Lidocaine injected monthly for 3 months with a 27 gauge needle on painful areas of the tibial tuberosity, under the patellar tendon.

OTHERUsual Care

Therapist supervised exercises that are standard of care for Osgood-Schatter Disease as well as relative rest and gradual resumption of pain-limited sport.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

9 Years to 17 Years

Healthy volunteers

Inclusion criteria

* Age:9-15 year old girls and 10-17 year old boys * Pain Location: Anterior knee. * Sport Type: Jumping or kicking sport. * Team Member with Coach: Member of and organized team with a coach. * Imitation of exact pain and precise location to the tibial tuberosity with a single leg squat. * At least 2 months of formal and gently progressive hamstring stretching, quads strengthening, and gradual sports reintroduction. * Pain with sport at least 3 months.

Exclusion criteria

* Patellofemoral crepitus * Patellar origin tenderness

Countries

Argentina

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026