Influence of Extracorporeal Circulation During Cardiac Surgery on the Development of Postoperative Thrombotic Thrombocytopenic Purpura (TTP)

Influence of Extracorporeal Circulation During Cardiac Surgery on the Development of Postoperative TTP

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01300117

Enrollment

Registered

2011-02-21

Start date

2010-10-31

Completion date

Unknown

Last updated

2011-12-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery

Keywords

cardiac surgery, adamts13, TTP, extracorporeal circulation, Heart-Lung Machine

Brief summary

The purpose of this study is to determine whether extracorporeal circulation during cardiac surgery has an influence on ADAMTS13-Activity.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* cardiac surgery with or without (OPCAB) the use of extracorporeal circulation * patient agrees

Exclusion criteria

* no agreement * known TTP in medical history

Design outcomes

Primary

Measure	Time frame
Change in ADAMTS13-Activity over time	during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery

Secondary

Measure	Time frame
Change in ADAMTS13-Antibody over time	during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery
Change in Platelet count over time	during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery
time duration of extracorporeal circulation during surgery	during surgery
Amount of intraoperative given fluid replacement	during surgery
Amount of given blood products (red blood cells)	24 hours

Countries

Germany

Contacts

Primary ContactWolfgang Miesbach

wolfgang.miesbach@kgu.de+49696301

Backup ContactImke R Reinecke

ireineck@stud.uni-frankfurt.de

Outcome results